Mesolite's spiritual meaning centers on spiritual growth, clarity, and communication with other realms, often called the "Stone of Harmony and Intuition," activating higher chakras (Crown, Third Eye) for mental clarity and spiritual perception, while also working with the Heart Chakra to foster compassionate relationships. It's used for bridging dimensions, enhancing intuitive understanding, and promoting inner peace and emotional balance, helping to alleviate stress and improve connections with others.