First edition of an important 1744 medical and philosophical satire targeting Bishop George Berkeley’s advocacy of “tar water” as a universal cure. Published anonymously (“By a certain R—t R—d Doctor”), this witty and acerbic pamphlet denounces the “epidemical madness” that swept across Britain and Ireland after Berkeley’s Siris appeared. Printed for John & Paul Knapton, noted London publishers of scientific and philosophical works. A key document in the public debate between reason, science, and superstition in 18th-century Britain. The book is complete, with 66 pages and later plain boards. Minor age wear but clean and legible throughout.