De vivorum organis generationi inservientibus, de clysteribus et de usu siphonis in anatomia, first edition. 12mo: xxii, 234pp; xiv index. Engraved title, portrait and 11 folding engraved plates. Several have ancient tear repairs, and one is split down part of the fold. ,, Title soiled and with short tears to fore-edge repaired and contemporary ink inscription cut away from head touching platemark, later ink inscriptions of the space pioneer Dr. Constantine Generales to front free endpapers, modern limp stained vellum, yapp edges. On the anatomy of the testicle and the male reproductive organ, with additional sections on enemas (clysters) and the author's improved siphon or syringe. This is an important first edition of a key work by the Dutch physician Reinier de Graaf, or Latinized Reijnerus de Graeff (1641 – 1673), whose anatomical researches were an important part of our understanding of reproductive biology. He was the first to develop a syringe to inject dye into human reproductive organs so that he could understand their structure and function. His eponymous legacy are the Graafian (or ovarian) follicles. He himself pointed out that he was not the first to describe them, but described their development. De Graaf described female ejaculation and referred to an erogenous zone in the vagina that he himself linked with the male prostate; this zone was later reported by German gynecologist Ernst Gräfenberg and named after him as the Gräfenberg Spot or G-Spot. Further, De Graaf described the anatomy of the testicles and collected secretions of the gall bladder and the pancreas, all detailed in this book.. The contents and binding (aside from the comments above) are excellent!